Journal
COMPUTERS IN BIOLOGY AND MEDICINE
Volume 120, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2020.103764
Keywords
Alzheimer; Deep learning; MRI; Sagittal; ANN; Transfer learning
Categories
Funding
- Collaborative Project in Genomic Data Integration (CICLOGEN) - Carlos III Health Institute [PI17/01826]
- European Regional Development Funds (FEDER)A way to build Europe''
- General Directorate of Culture, Education and University Management of Xunta de Galicia [ED431G/01, ED431D 2017/16]
- Galician Network for Colorectal Cancer Research [ED431D 2017/23]
- Spanish Ministry of Economy and Competitiveness [UNLC08-1E-002, UNLC13-13-3503]
- European Regional Development Funds (FEDER)
- CESGA
- [ED431C 2018/49]
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Early detection is crucial to prevent the progression of Alzheimer's disease (AD). Thus, specialists can begin preventive treatment as soon as possible. They demand fast and precise assessment in the diagnosis of AD in the earliest and hardest to detect stages. The main objective of this work is to develop a system that automatically detects the presence of the disease in sagittal magnetic resonance images (MRI), which are not generally used. Sagittal MRIs from ADNI and OASIS data sets were employed. Experiments were conducted using Transfer Learning (TL) techniques in order to achieve more accurate results. There are two main conclusions to be drawn from this work: first, the damages related to AD and its stages can be distinguished in sagittal MRI and, second, the results obtained using DL models with sagittal MRIs are similar to the state-of-the-art, which uses the horizontal-plane MRI. Although sagittal-plane MRIs are not commonly used, this work proved that they were, at least, as effective as MRI from other planes at identifying AD in early stages. This could pave the way for further research. Finally, one should bear in mind that in certain fields, obtaining the examples for a data set can be very expensive. This study proved that DL models could be built in these fields, whereas TL is an essential tool for completing the task with fewer examples.
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