Journal
CELL HOST & MICROBE
Volume 19, Issue 5, Pages 575-578Publisher
CELL PRESS
DOI: 10.1016/j.chom.2016.04.014
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Human microbiota-associated (HMA) mice have been used extensively in gut microbiome research. Here we discuss ecological and evolutionary aspects of the mammalian-gut microbiome interrelationship that confound the application of HMA mice, and propose experimental designs that increase the likelihood for obtaining meaningful findings.
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