Journal
CELL HOST & MICROBE
Volume 19, Issue 2, Pages 139-141Publisher
CELL PRESS
DOI: 10.1016/j.chom.2016.01.012
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Dysregulated type I interferon (IFN-I) expression can lead to severe pathology and disease. In this issue of Cell Host & Microbe, Channappanavar et al. (2016) use a SARS-coronavirus animal model to describe how rapid and robust virus replication with delayed IFN-I can lead to lung immunopathology, with fatal outcomes.
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