Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 188, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.110826
Keywords
Polylactic acid; Microchambers arrays; Biodegradable; Cargo encapsulation; pH stability
Funding
- Key Laboratory of Micro-systems and Micro-structures Manufacturing Ministry of Education, Harbin Institute of Technology, Harbin, China [2016KM008]
- Chinese Scholarship Council (CSC) [201406120038]
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Encapsulation of small water soluble molecules is important in a large variety of applications, ranging from medical substance releasing implants in the field of medicine over release of catalytically active substances in the field of chemical processing to anti-corrosion agents in industry. In this work polylactic acid (PLA) based hollow-structured microchamber (MC) arrays are fabricated via one-step dip coating of a silicone rubber stamp into PLA solution. These PLA MCs are able to retain small water soluble molecules (Rhodamine B) stably entrapped within aqueous environments. It is shown, that degradation of PLA MCs strongly depends on environmental conditions like surrounding pH and follows first order degradation kinetics. This pH dependent PLA MC degradation can be utilized to control the release kinetics of encapsulated cargo.
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