Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 602, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfa.2020.125049
Keywords
Nanosponges; Artemether; Lumefantrine; Antimalarial study; Pharmacokinetics; Factorial design
Categories
Ask authors/readers for more resources
To improve the physicochemical properties of artemether and lumefantrine, cyclodextrin-based carriers like nanoparticle, microcomplex, nanosponges, etc. play a significant role in the development of dosage forms. The current study focused on the formulation of cyclodextrin-based artemether and lumefantrine-loaded nanosponges to improve the solubility and stability of actives with controlled-release profile. Nanosponges were synthesized using solvent evaporation method and statistically optimized using 2(3) full factorial designs. Nanosponges showed mean particle size of 316.4 +/- 8.5 nm and % entrapment efficiencies of 70.6 +/- 1.5 % and 88.3 +/- 2.5 % for artemether and lumefantrine, respectively. SEM and TEM analysis revealed the spherical structure of nanosponges with porous surfaces. In-vitro release study of nanosponges showed controlled-release of actives fill 24 h. In-vitro antimalarial study showed significant action of nanosponges towards RKL-9 strains in comparison to MRC-2 strains. The pharmacokinetic study of nanosponges showed that the parameters (Cmax and AUC) were under the acceptable limits with increased mean residence time of actives in the blood circulation. The data of stability study demonstrated that nanosponges were stable at 40 degrees C for 3 months. Thus, hypercross-linked cyclodextrin nanosponges advance as a novel nanocarrier system for controlled-release formulations of BCS class II and IV drugs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available