Journal
CLINICS IN DERMATOLOGY
Volume 38, Issue 4, Pages 421-431Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.clindermatol.2020.03.005
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Cafe au lait spots are common birthmarks seen sporadically and in association with several genetic syndromes. Dermatologists are often asked to evaluate these birthmarks both by other physicians and by parents. In some cases, it is challenging to know when and how to pursue further evaluation. Diagnostic challenges may come in the form of the appearance of the individual lesions, areas and patterns of cutaneous involvement, and associated features (or lack thereof). In this review, we aim to clarify when and how to evaluate the child with multiple or patterned cafe au lait spots and to explain some emerging concepts in our understanding of the genetics of these lesions. (C) 2020 Elsevier Inc. All rights reserved.
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