Journal
CLINICAL THERAPEUTICS
Volume 42, Issue 6, Pages 1007-1014Publisher
ELSEVIER
DOI: 10.1016/j.clinthera.2020.05.002
Keywords
Atopic dermatitis; Autism spectrum disorder; Corticotropin-releasing hormone; Inflammation; Mast cells; Stress
Categories
Ask authors/readers for more resources
Purpose: Psychological stress worsens many diseases, especially those with inflammatory components, such as atopic dermatitis (AD) and autism spectrum disorder (ASD), conditions that are significantly correlated in large epidemiologic studies. However, how stress contributes to these conditions is still poorly understood. This narrative review of the relevant literature advances the premise that stress affects inflammatory processes in AD and ASD via stimulation of mast cells (MCs). Methods: MEDLINE was searched between 1980 and 2019 using the terms allergies, atopic dermatitis, autism spectrum disorder, brain, corticotropin-releasing hormone, inflammation, hypothalamic pituitary-adrenal axis, mast cells, neuropeptides, stress, neurotensin, and substance P. Findings: Exposure to psychological stress is associated with onset and/or exacerbation of AD and ASD. This association could be attributable to activation of MCs, which are ubiquitous in the body, including the brain, and could contribute to inflammation. (C) 2020 Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available