Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 108, Issue 2, Pages 191-200Publisher
WILEY
DOI: 10.1002/cpt.1830
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Funding
- National Institutes of Health (NIH) [R24GM115264, U24HG010135, R24GM61374, U24HG010615, R24 GM123930]
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Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used analgesics due to their lack of addictive potential. However, NSAIDs have the potential to cause serious gastrointestinal, renal, and cardiovascular adverse events. CYP2C9 polymorphisms influence metabolism and clearance of several drugs in this class, thereby affecting drug exposure and potentially safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for NSAIDs based on CYP2C9 genotype (updates at ).
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