Journal
CELL CYCLE
Volume 16, Issue 19, Pages 1739-1743Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2016.1231284
Keywords
acid adaptation; cancer microenvironment; evolution; phenotype
Categories
Funding
- NCI NIH HHS [P30 CA076292] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P30CA076292] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The inter- and intra-tumoral metabolic phenotypes of tumors are heterogeneous, and this is related to microenvironments that select for increased glycolysis. Increased glycolysis leads to decreased pH, and these local microenvironment effects lead to further selection. Hence, heterogeneity of phenotypes is an indirect consequence of altering microenvironments during carcinogenesis. In early stages of growth, tumors are stratified, with the most aggressive cells developing within the acidic interior of the tumor. However, these cells eventually find themselves at the tumor edge, where they invade into the normal tissue via acid-mediated invasion. We believe acid adaptation during the evolution of cancer cells in their niche is a Rubicon that, once crossed, allows cells to invade into and outcompete normal stromal tissue. In this study, we illustrate some acid-induced phenotypic changes due to acidosis resulting in more aggressiveness and invasiveness of cancer cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available