Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 26, Issue 12, Pages 1617-1621Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cmi.2020.02.028
Keywords
Antibiotic; Antivirulence; Bacteriophage; Genetics; Genomics; Microbiome; Vaccine
Categories
Funding
- Biotechnology and Biological Sciences Research Council (BBSRC) [BBS/E/D/20002172, BBS/E/D/20002173, BBS/E/D/20002174]
- BBSRC [BB/N001591/1, BB/K015524/1, BB/M028305/1, BB/P02095X/1, BB/J004227/1, BB/P007767/1]
- NERC [NE/N020162/1]
- University of Strathclyde
- Medical, Veterinary and Life Sciences Doctoral Training Programme at the University of Glasgow
- BBSRC [BB/N001591/1, BB/P007767/1, BBS/E/D/20002173, BBS/E/D/20002174, BB/P02095X/1, BB/M028305/1, BB/K015524/1] Funding Source: UKRI
- NERC [NE/N020162/1, NE/N019806/1] Funding Source: UKRI
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Background: This review follows on from the International Conference on One Health Antimicrobial Resistance (ICOHAR 2019), where strategies to improve the fundamental understanding and management of antimicrobial resistance at the interface between humans, animals and the environment were discussed. Objective: This review identifies alternatives to antimicrobials in a One Health context, noting how advances in genomic technologies are assisting their development and enabling more targeted use of antimicrobials. Sources: Key articles on the use of microbiota modulation, livestock breeding and gene editing, vaccination, antivirulence strategies and bacteriophage therapy are discussed. Content: Antimicrobials are central for disease control, but reducing their use is paramount as a result of the rise of transmissible antimicrobial resistance. This review discusses antimicrobial alternatives in the context of improved understanding of fundamental host-pathogen and microbiota interactions using genomic tools. (C) 2020 Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases.
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