Journal
CLINICAL INFECTIOUS DISEASES
Volume 71, Issue 16, Pages 2272-2275Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciaa577
Keywords
COVID-19; inflammation; NK cells; cytotoxic cells; MDSC
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Funding
- Italian Ministry of Health (Ricerca Corrente Linea 1)
- European and Developing Countries Clinical Trials Partnership under Horizon 2020
- National Institute for Health Research
- Champalimaud Foundation
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Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3(+) T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.
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