Journal
CLINICAL IMMUNOLOGY
Volume 217, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2020.108487
Keywords
Coronavirus disease 2019 (COVID-19); Severe Acute Respiratory Syndrome; Coronavirus 2 (SARS-CoV-2); Type III hypersensitivity; Immune complex disease; Vasculitis; Interleukin-6 (IL-6)
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Coronavirus Disease 2019 (COVID-19) is an ongoing public health emergency and new knowledge about its immunopathogenic mechanisms is deemed necessary in the attempt to reduce the death burden, globally. For the first time in worldwide literature, we provide scientific evidence that in COVID-19 vasculitis a life-threatening escalation from type 2 T-helper immune response (humoral immunity) to type 3 hypersensitivity (immune complex disease) takes place. The subsequent deposition of immune complexes inside the vascular walls is supposed to induce a severe inflammatory state and a cytokine release syndrome, whose interleukin-6 is the key myokine, from the smooth muscle cells of blood vessels.
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