Oxidative stress, microRNAs and cytosolic calcium homeostasis

Reactive oxygen species increase cytosolic [Ca2+], (Ca-i), and also modulate the expression of some microRNAs (miRNAs), however the link among oxidative stress, miRNAs and Ca-i is poorly characterized. In this review we have focused on three groups of miRNAs: (a) miRNAs that are modulated both by ROS and Ca-i: miR-181a and miR-205; (b) miRNAs that are modulated by ROS and have an effect on Ca-i: miR-1, miR-21, miR-24, miR-25, miR-185 and miR-214; (c) miRNAs that modulate both ROS and Ca-i: miR-133; miR-145, miR-495, and we have analyzed their effects on cell signaling and cell function. Finally, in the last section we have examined the role of these miRNAs in the skin, under conditions associated with enhanced oxidative stress, i.e. skin aging, the response to ultraviolet light and two important skin diseases, psoriasis and atopic dermatitis. It is apparent that although some experimental evidence is already available on (a) the role of Ca-i in miRNAs expression and (b) on the ability of some miRNAs to modulate Ca-i-dependent intracellular signaling, these research lines are still largely unexplored and represent important areas of future studies. (C) 2016 Elsevier Ltd. All rights reserved.