Journal
CELL BIOLOGY INTERNATIONAL
Volume 40, Issue 9, Pages 1017-1023Publisher
WILEY
DOI: 10.1002/cbin.10630
Keywords
BMSCs; differentiation; hepatocyte; indocyanine green; NF-kappa B
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Funding
- National Natural Science Foundation of China [30772000]
- ShanDong Natural Science Foundation [ZR2012CM008]
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Hepatocyte growth factor (HGF) is multifaceted cytokine that regulates proliferation, differentiation, morphology, and motility within numerous stem cells. More recently, HGF has been reported to induce the differentiation of bone mesenchymal stem cells (BMSCs) into mature hepatocytes, but the underlying biochemical and molecular signaling is largely unknown. We isolated BMSC from the bone marrow of rats, which were then cultured and exposed to HGF for 15 days. We subsequently assayed these cells for liver functionality and markers, and blocked NF-kB signaling at various stages of the pathway. The present results demonstrate that HGF induces the differentiation of BMSCs toward hepatocyte-like cells through the NF-kB signaling. More specifically, HGF upregulated the translocation of NF-kB to the nucleus.
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