Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 15, Issue 14, Pages 2076-2091Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202000493
Keywords
lanthanide nanoprobes; near-infrared bioimaging; upconversion; downconversion; photoacoustic; lifetime
Categories
Funding
- MOE [2017-T2-2-110]
- A*Star SERC [A1983c0028 (M4070319)]
- National Natural Science Foundation of China (NSFC) [51929201]
- [RG5/18 (S)]
- [SPMS-M4082042.110]
Ask authors/readers for more resources
Optical imaging plays a growing role in modern biomedical research and clinical applications due to its high sensitivity, superb spatiotemporal resolution and minimal hazards. Lanthanide-doped nanoparticles (LDNPs), as a classical category of luminescent materials, exhibit promising photostability, near-infrared (NIR)-excited frequency up-/down-converting capabilities, emission fine-tuning and multispectral features, which have greatly promoted the endeavors of deeper and clearer diagnostics in complex living conditions. This review focuses on the recent advances of LDNP-based multipurpose imaging studies using upconversion, downshifting, lifetime, photoacoustic and multimodal nanoprobes in the NIR (650-1000 nm) and the second near-infrared window (NIR-II, 1000-1700 nm). The principle and design of various functional, activatable, multiplexing or multimodal lanthanide-imaging nanoprobes (LINPs) as well as representative biophotonic applications are summarized in detail. In addition, the future perspectives and challenges for facilitating LINPs to clinical translations are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available