Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 26, Issue 30, Pages 6784-6788Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202001439
Keywords
anilines; ortho-substitution; perfluoroalkylation; Ru catalyst; site-selectivity
Categories
Funding
- BMBF
- State of Mecklenburg-Western Pomerania, Germany
- Chinese Scholarship Council, China
Ask authors/readers for more resources
Introducing (per)fluoroalkyl groups into arenes continues to be an interesting, but challenging area in organofluorine chemistry. We herein report an ortho-selective C-H perfluoroalkylation including trifluoromethylations of anilines and indoles without the need of protecting groups using RfI and RfBr as commercially available reagents. The availability and price of the starting materials and the inherent selectivity make this novel methodology attractive for the synthesis of diverse (per)fluoroalkylated building blocks, for example, for bioactive compounds and materials.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available