Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 26, Issue 37, Pages 8239-8243Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202002410
Keywords
1; 4-dihydropyridines; carbamoyl radicals; Giese reaction; organic dyes; photoredox catalysis
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Funding
- University of Hamburg
- Alexander von Humboldt Foundation
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Functionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C-1-molecule, carbon dioxide, makes alternative carboxylation reactions with CO2-surrogates especially important. We report a photoredox-catalyzed protocol for alkene carbamoylations. Readily accessible 4-carboxamido-Hantzsch esters serve as convenient starting materials that generate carbamoyl radicals upon visible light-mediated single-electron transfer. Addition to various alkenes proceeded with high levels of regio- and chemoselectivity.
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