Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 26, Issue 38, Pages 8452-8457Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202001349
Keywords
antimicrobial; gel; nanoparticle; self-assembly; supramolecular chemistry
Categories
Funding
- EPSRC [EP/P03361X/1]
- European Commission Marie Curie IF Scheme [702927]
- EPSRC [EP/P03361X/1] Funding Source: UKRI
- Marie Curie Actions (MSCA) [702927] Funding Source: Marie Curie Actions (MSCA)
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This Full Paper reports the formation of silver (Ag) NPs within spatially resolved two-component hydrogel beads, which combine a low-molecular-weight gelator (LMWG) DBS-CONHNH(2)and a polymer gelator (PG) calcium alginate. The AgNPs are formed through in situ reduction of Ag-I, with the resulting nanoparticle-loaded gels being characterised in detail. The antibacterial activity of the nanocomposite gel beads was tested against two drug-resistant bacterial strains, often associated with hospital-acquired infections: vancomycin-resistantEnterococcus faecium(VRE) andPseudomonas aeruginosa(PA14), and the AgNP-loaded gels showed good antimicrobial properties against both types of bacteria. It is suggested that the gel bead format of these AgNP-loaded hybrid hydrogels makes them promising versatile materials for potential applications in orthopaedics or wound healing.
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