Synthesis of Diverse Aromatic Ketones through C-F Cleavage of Trifluoromethyl Group

An efficient synthetic method of aromatic ketones through C-F cleavage of trifluoromethyl group is disclosed. The high functional group tolerance of the transformation and the remarkable stability of trifluoromethyl group in various reactions enabled multi-substituted aromatic ketone synthesis in an efficient route involving useful transformations such asortho-lithiation, aryne chemistry, and cross-couplings.