Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 26, Issue 37, Pages 8220-8225Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202000781
Keywords
cavitands; diffusion; DOSY; exchange; inclusion complexes
Categories
Funding
- Gobierno de Espana MINECO [CTQ2017-84319-P]
- FEDER funds [CTQ2017-84319-P]
- CERCA Programme/Generalitat de Catalunya
- AGAUR [2017 SGR 1123]
- MECD [FPU14/01016]
Ask authors/readers for more resources
A deep cavitand binds long-chain trans,trans- and trans,cis-bis-formamide isomers in water solution giving a pair of caviplexes in a ca. 60:40 ratio. Both caviplexes display in/out guest exchange dynamics that are slow on the H-1 NMR chemical shift timescale, but fast on the EXSY timescale. We apply diffusion-ordered NMR spectroscopy (DOSY) to characterize the caviplexes. On the diffusion timescale, the guest in/out exchange processes feature intermediate dynamics allowing the assessment of their kinetic stabilities. We found that the trans,cis-bis-formamide isomers form kinetically more stable caviplexes than the trans,trans-counterparts. We also show that the kinetic stabilities of the bis-formamide caviplexes relate well with their relative thermodynamic stabilities. Fortunately, the tuning of the DOSY parameters allowed the observation of the exchange dynamics as slow processes on the experiment timescale.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available