Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 26, Issue 53, Pages 12129-12133Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202001697
Keywords
alkynes; cobalt; enynes; hydroalkynylation; stereoselectivity
Categories
Funding
- Projekt DEAL
Ask authors/readers for more resources
A diastereoselective hydroalkynylation of terminal alkynes to form the head-to-head dimerization products by two different cobalt-phosphine catalyst system is reported. The use of the bidentate ligand dppp and additional triphenylphosphine led to the selective formation of the(E)-1,3-enynes (E:Z>99:1) in good to excellent yields, while the tridentate ligand TriPhos led to the corresponding (Z)-1,3-enynes in moderate to good yields with excellent stereoselectivities (up toE:Z=1:99). Both pre-catalysts are easy to handle, because of their stability under atmospheric conditions. The optimized reaction conditions were identified by the Design of Experiments (DoE) approach, which has not been used before in cobalt-catalysed reaction optimisation. DoE decreased the number of required reactions to a minimum.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available