Journal
CELL AND TISSUE RESEARCH
Volume 367, Issue 3, Pages 737-745Publisher
SPRINGER
DOI: 10.1007/s00441-016-2517-4
Keywords
Preterm; Lung injury; Bronchopulmonary dysplasia; Mesenchymal stem cell; Regeneration
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Preterm birth occurs in approximately 11 % of all births worldwide. Advances in perinatal care have enabled the survival of preterm infants born as early as 23-24 weeks of gestation. However, many are affected by bronchopulmonary dysplasia (BPD)-a common respiratory complication of preterm birth, which has life-long consequences for lung health. Currently, there is no specific treatment for BPD. Recent advances in stem cell research have opened new therapeutic avenues for prevention/repair of lung damage. This review summarizes recent pre-clinical data and early clinical translation of cell-based therapies for BPD.
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