Journal
CHEMISTRY & BIODIVERSITY
Volume 17, Issue 6, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202000178
Keywords
biotransformation; ent-kaur-16-en-19-oic acid; Cunninghamella echinulata; cytotoxicity
Funding
- NSFC [31870332, 31470414]
- Basic Research Funds from the Central University
- Central Government Level: the capacity Establishment of Sustainable Use of Rare Chinese Medicinal Resources [2060302]
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Biotransformation of ent-kaur-16-en-19-oic acid using fungus Cunninghamella echinulata resulted in two novel hydroxylated metabolites together with five known compounds. Their structures were elucidated by means of extensive NMR and HR-ESI-MS data analysis. The eight compounds were measured for their cytotoxicity against the human breast carcinoma (MCF-7) and human hepatoblastoma (HepG-2) cell lines. Seven compounds showed no cytotoxicity to the two cell lines. One compound displayed moderate cytotoxicity against HepG-2 and MCF-7 with the IC50 values of 12.6 and 27.1 mu M, respectively.
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