Journal
CHEMISTRY & BIODIVERSITY
Volume 17, Issue 4, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201900674
Keywords
limonoid; Melia toosendan; Meliaceae; UFLC; MS-IT-TOF; antifeedant activity; biological activity
Funding
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [18KJB350011]
- Natural Research Foundation for Advanced Talents of Taizhou university [QD2016010, QD2016044]
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The fruits of Melia toosendan Sieb. et Zucc. (Meliaceae) are a source of bioactive limonoids that can be used as effective pesticides. In this study, two novel limonoids, 6-acetylsendanal and 6-ketocinamodiol, were isolated together with fourteen known compounds, namely four protolimonoids, six trichilin-class limonoids, and four C-seco limonoids. The structures of the new compounds were determined by extensive spectroscopic analyses (HR-ESI-MS, UV, IR, 1D and 2D NMR). The bioassay results revealed that eleven of the extracted limonoids exhibited interesting antifeedant activities against the larvae of Pieris rapae with AFC(50) values in the range of 0.11-1.79 mm. Particularly, mesendanin H, with an AFC(50) value of 0.11 mm, exhibited a higher activity than the positive control toosendanin. Information on new bioactive limonoids may provide further insight into M. toosendan as a source of bioactive components.
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