Journal
CHEMISTRY & BIODIVERSITY
Volume 17, Issue 6, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202000170
Keywords
Stachybotrys chartarum; chartarlactams Q-T; structure elucidation; antivirus activity; antibacterial activity
Funding
- National Natural Science Foundation of China [81991525, 21861142006, 81872793, 81630089]
- MOST [2018ZX09711001-001-008]
- COMRA [DY135-B-05]
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Four new phenylspirodrimane-type dimers, namely chartarlactams Q-T, along with stachyin B were isolated from the fermentation broth of a sponge-derived fungus Stachybotrys chartarum WGC-25 C-6. Chartarlactams Q-T were structurally featured by the dimerization of two units of phenylspirodrimane linked by a C-N bond. Their structures were determined on the basis of extensive spectroscopic analysis, while quantum ECD calculation and modified Mosher's method were used for the assignment of absolute configurations. Chartarlactams Q-S and stachyin B showed moderate inhibition against bacterial pathogen Staphylococcus aureus with MIC values ranging from 4 mu g/mL to 16 mu g/mL, and chartarlactam T exhibited significant inhibition toward ZIKV virus.
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