Journal
CELL
Volume 164, Issue 3, Pages 487-498Publisher
CELL PRESS
DOI: 10.1016/j.cell.2015.12.038
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Funding
- Howard Hughes Medical Institute
- [NIH-F30N2093682]
- [NSF-IIP-1353638]
- [NIH-GM045443]
- Directorate For Engineering
- Div Of Industrial Innovation & Partnersh [1353638] Funding Source: National Science Foundation
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Stress granules are mRNA-protein granules that form when translation initiation is limited, and they are related to pathological granules in various neurodegenerative diseases. Super-resolution microscopyreveals stable substructures, referred to as cores, within stress granules that can be purified. Proteomic analysis of stress granule cores reveals a dense network of protein-protein interactions and links between stress granules and human diseases and identifies ATP-dependent helicases and protein remodelers as conserved stress granule components. ATP is required for stress granule assembly and dynamics. Moreover, multipleATP-drivenmachines affect stress granules differently, with the CCT complex inhibiting stress granule assembly, while the MCM and RVB complexes promote stress granule persistence. Our observations suggest that stress granules contain a stable core structure surrounded by a dynamic shell with assembly, disassembly, and transitions between the core and shell modulated by numerous protein and RNA remodeling complexes.
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