Journal
CHEMICAL ENGINEERING JOURNAL
Volume 388, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2020.124212
Keywords
Carbon dots; PDT; PTT; Two-photon excited; Photoacoustic imaging
Categories
Funding
- External Cooperation Program of Chinese Academy of Sciences [GJHZ1723]
- National Natural Science Foundation of China [61720106014, 61805287]
- Natural Science Foundation of Hunan Province, China [2018JJ3632, 2019JJ50824]
- Fundamental Research Funds for the Central Universities [202045002]
- Basic Research Foundation of Shenzhen Science and Technology Innovation [JCYJ20180307151245919]
- General Research Fund of Hong Kong (GRF) [CityU 11306717, CityU 11338516]
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Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT) holds great potential for efficient cancer therapy by inducing reactive oxygen species (ROS) or heat into tumor. Nevertheless, PDT or PTT suffers from some limitations, e.g., PTT requires long-time and high-power laser irradiation to generate enough heat, while the hypoxia microenvironment of tumor and the limit diffuse distance of ROS hamper the efficacy of oxygen-dependent PDT. Here we reported the carbon dots (CDs) which could simultaneously generate singlet oxygen (O-1(2)), hydroxyl radical (OH center dot), and heat under a 635 nm laser irradiation, with a O-1(2) generation quantum yield of 5.7% and photothermal conversion efficiency of 73.5% (the highest thus far for CDs). Significantly, the CDs can selectively accumulate in lysosome, which is an ideal organelle for phototherapy because of its key role in sustaining cellular activity and stability. Moreover, the CDs present one-photon excited (OPE) and two-photon excited (TPE) fluorescence, and excellent photoacoustic (PA) imaging capability. Combining the good biocompatibility, the as-prepared CDs was served as multi-functional phototheranostic agent for synergistic PA/fluorescence imaging, and PDT/PTT.
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