Journal
CELL
Volume 164, Issue 6, Pages 1110-1121Publisher
CELL PRESS
DOI: 10.1016/j.cell.2016.02.007
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Categories
Funding
- National Human Genome Research Institute [R01 HG003143, U54 HG007010, U01 HG007910]
- National Cancer Institute [U54 CA193419]
- NIH Common Fund [U54 DK107980, U01 DA 040588]
- National Institute of General Medical Sciences [R01 GM 112720]
- National Institute of Allergy and Infectious Diseases [U01 R01 AI 117839]
- Division Of Physics
- Direct For Mathematical & Physical Scien [1504942] Funding Source: National Science Foundation
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Proper expression of genes requires communication with their regulatory elements that can be located elsewhere along the chromosome. The physics of chromatin fibers imposes a range of constraints on such communication. The molecular and biophysical mechanisms by which chromosomal communication is established, or prevented, have become a topic of intense study, and important roles for the spatial organization of chromosomes are being discovered. Here we present a view of the interphase 3D genome characterized by extensive physical compartmentalization and insulation on the one hand and facilitated long-range interactions on the other. We propose the existence of topological machines dedicated to set up and to exploit a 3D genome organization to both promote and censor communication along and between chromosomes.
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