Journal
CELL
Volume 165, Issue 5, Pages 1055-1066Publisher
CELL PRESS
DOI: 10.1016/j.cell.2016.05.004
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Funding
- NIAID NIH HHS [R01 AI124491, R01 AI050872, R01 AI045937] Funding Source: Medline
- NICHD NIH HHS [DP1 HD087988] Funding Source: Medline
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We here attempt to achieve an integrated understanding of the structure and dynamics of a number of higher-order assemblies, including amyloids, various kinds of signalosomes, and cellular granules. We propose that the synergy between folded domains, linear motifs, and intrinsically disordered regions regulates the formation and intrinsic fuzziness of all higher-order assemblies, creating a structural and dynamic continuum. We describe how such regulatory mechanisms could be influenced under pathological conditions.
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