4.8 Editorial Material

NADH Ties One-Carbon Metabolism to Cellular Respiration

Journal

CELL METABOLISM
Volume 31, Issue 4, Pages 660-662

Publisher

CELL PRESS
DOI: 10.1016/j.cmet.2020.03.012

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Funding

  1. Landry Cancer Research Fellowship
  2. Charles H. Hood Foundation
  3. Pathology Department at Boston Children's Hospital

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In this issue of Cell Metabolism, Yang et al., 2020 report that serine is a source of mitochondrial NADH derived from one-carbon metabolism. Serine becomes a major source of NADH when cellular respiration is inhibited, and the un-utilized, accumulated NADH inhibits the TCA cycle and slows proliferation.

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