Journal
CELL HOST & MICROBE
Volume 27, Issue 4, Pages 519-530Publisher
CELL PRESS
DOI: 10.1016/j.chom.2020.03.014
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Funding
- Chan Zuckerberg Biohub
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [UM1AI126611]
- Canadian HIV Cure Enterprise (CanCURE) Team Grant from the Canadian Institutes of Health [HIG-133050]
- Canadian Foundation for AIDS Research
- Research Scholar Career Awards of the Fonds de Recherche Quebec Sante [253292]
- amfAR Institute for HIV Cure Research [amfAR 109301]
- Delaney AIDS Research Enterprise (DARE) [A127966]
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Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the integrated HIV genome persists indefinitely within CD4(+) T cells and perhaps other cells. Here, we describe the mechanisms thought to contribute to its persistence during treatment and highlight findings from numerous recent studies describing the importance of cell proliferation in that process. Continued progress elucidating the biology will enhance our ability to develop effective curative interventions.
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