Journal
CELL
Volume 181, Issue 1, Pages 81-91Publisher
CELL PRESS
DOI: 10.1016/j.cell.2020.03.003
Keywords
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Categories
Funding
- ERC [EMPSI 339995]
- Heptares Therapeutics
- Medical Research Council [MRC U105197215]
- MRC [MC_U105197215] Funding Source: UKRI
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Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with over 370 structures in total bound to different ligands and the receptors in various conformational states. Structure-based drug design has been applied to an increasing number of GPCR targets over the past decade and now a few of these drug candidates have entered clinical trials. Given the length of time required for a drug to reach the market, there are no documented examples of licensed drugs being developed with the aid of a structure, but this is likely to change as current efforts come to fruition.
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