4.8 Review

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

Journal

CELL
Volume 181, Issue 1, Pages 63-80

Publisher

CELL PRESS
DOI: 10.1016/j.cell.2020.03.007

Keywords

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Funding

  1. Wellcome Trust [100308/Z/12/Z]
  2. Oak Foundation [OCAY-15-520]
  3. NIHR Oxford BRC
  4. MRC UK
  5. Australian Research Council [FL160100049]
  6. Wellcome Trust [100308/Z/12/Z] Funding Source: Wellcome Trust
  7. Australian Research Council [FL160100049] Funding Source: Australian Research Council

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Autoimmune diseases are a result of the immune system being misdirected toward its host and have major and increasing unmet clinical needs. In general, present therapies are broadly acting and non-disease specific; consequently, they are associated with numerous side effects. Precise and early intervention strategies are urgently needed. We highlight the challenges, progress, and prospects in achieving these goals.

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