Related references
Note: Only part of the references are listed.Randomized, double-blind, placebo-controlled, multicentre pilot study on the effects of empagliflozin on clinical outcomes in patients with acute decompensated heart failure (EMPA-RESPONSE-AHF)
Kevin Damman et al.
EUROPEAN JOURNAL OF HEART FAILURE (2020)
Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure
Hideo Nambu et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2020)
Empagliflozin reduces myocardial ketone utilization while preserving glucose utilization in diabetic hypertensive heart disease: A hyperpolarized 13C magnetic resonance spectroscopy study
Desiree Abdurrachim et al.
DIABETES OBESITY & METABOLISM (2019)
SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob-/- mice
Damilola D. Adingupu et al.
CARDIOVASCULAR DIABETOLOGY (2019)
SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart
Chenguang Li et al.
CARDIOVASCULAR DIABETOLOGY (2019)
Effect of Dapagliflozin on Heart Failure and Mortality in Type 2 Diabetes Mellitus
Eri T. Kato et al.
CIRCULATION (2019)
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients
Roni Nielsen et al.
CIRCULATION (2019)
Phloretin protects against cardiac damage and remodeling via restoring SIRT1 and anti-inflammatory effects in the streptozotocin-induced diabetic mouse model
Yin Ying et al.
AGING-US (2019)
Inhibition of sodium-glucose cotransporter-2 preserves cardiac function during regional myocardial ischemia independent of alterations in myocardial substrate utilization
Hana E. Baker et al.
BASIC RESEARCH IN CARDIOLOGY (2019)
Sodium-glucose co-transporter 2 inhibition with empagliflozin improves cardiac function in non-diabetic rats with left ventricular dysfunction after myocardial infarction
Salva R. Yurista et al.
EUROPEAN JOURNAL OF HEART FAILURE (2019)
Loop diuretic use among patients with heart failure and type 2 diabetes treated with sodium glucose cotransporter-2 inhibitors
Erin R. Weeda et al.
JOURNAL OF DIABETES AND ITS COMPLICATIONS (2019)
Empagliflozin Ameliorates Adverse Left Ventricular Remodeling in Nondiabetic Heart Failure by Enhancing Myocardial Energetics
Carlos G. Santos-Gallego et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)
Acute canagliflozin treatment protects against in vivo myocardial ischemia-reperfusion injury in non-diabetic male rats and enhances endothelium-dependent vasorelaxation
Alex Ali Sayour et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2019)
Dapagliflozin Effects on Biomarkers, Symptoms, and Functional Status in Patients With Heart Failure With Reduced Ejection Fraction The DEFINE-HF Trial
Michael E. Nassif et al.
CIRCULATION (2019)
Effects of the sodium-glucose co-transporter-2 inhibitor dapagliflozin on estimated plasma volume in patients with type 2 diabetes
Claire C. J. Dekkers et al.
DIABETES OBESITY & METABOLISM (2019)
Effect of ipragliflozin, an SGLT2 inhibitor, on cardiac histopathological changes in a non-diabetic rat model of cardiomyopathy
Toshiyuki Takasu et al.
LIFE SCIENCES (2019)
Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction
J. J. V. McMurray et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Inducible Cardiac-Specific Deletion of Sirt1 in Male Mice Reveals Progressive Cardiac Dysfunction and Sensitization of the Heart to Pressure Overload
Maria-Nieves Sanz et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Epithelial sodium channels in endothelial cells mediate diet-induced endothelium stiffness and impaired vascular relaxation in obese female mice
James R. Sowers et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2019)
Hypoxia-inducible factor-1α is the therapeutic target of the SGLT2 inhibitor for diabetic nephropathy
Ryoichi Bessho et al.
SCIENTIFIC REPORTS (2019)
Sirt1-hypoxia-inducible factor-1α interaction is a key mediator of tubulointerstitial damage in the aged kidney
Dong Ryeol Ryu et al.
AGING CELL (2019)
Empagliflozin reduces the levels of CD36 and cardiotoxic lipids while improving autophagy in the hearts of Zucker diabetic fatty rats
Alana Aragon-Herrera et al.
BIOCHEMICAL PHARMACOLOGY (2019)
HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury
Yanan Zhang et al.
BIOMEDICINE & PHARMACOTHERAPY (2019)
Finely-tuned regulation of AMP-activated protein kinase is crucial for human adult erythropoiesis
Meriem Ladli et al.
HAEMATOLOGICA (2019)
Dapagliflozin not only improves hepatic injury and pancreatic endoplasmic reticulum stress, but also induces hepatic gluconeogenic enzymes expression in obese rats
Myat Theingi Swe et al.
CLINICAL SCIENCE (2019)
SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials
Thomas A. Zelniker et al.
LANCET (2019)
Effects of the sodium-glucose cotransporter 2 inhibitor dapagliflozin on fluid distribution: A comparison study with furosemide and tolvaptan
Ken Ohara et al.
NEPHROLOGY (2019)
Empagliflozin attenuates diabetic tubulopathy by improving mitochondrial fragmentation and autophagy
Yu Ho Lee et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2019)
SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms
Soravis Osataphan et al.
JCI INSIGHT (2019)
The Role of Autophagy in the Heart
Sebastiano Sciarretta et al.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 80 (2018)
Canagliflozin exerts anti-inflammatory effects by inhibiting intracellular glucose metabolism and promoting autophagy in immune cells
Chenke Xu et al.
BIOCHEMICAL PHARMACOLOGY (2018)
MicroRNA-204 protects H9C2 cells against hypoxia/reoxygenation-induced injury through regulating SIRT1-mediated autophagy
Ruixia Qiu et al.
BIOMEDICINE & PHARMACOTHERAPY (2018)
Have dipeptidyl peptidase-4 inhibitors ameliorated the vascular complications of type 2 diabetes in large-scale trials? The potential confounding effect of stem-cell chemokines
Milton Packer
CARDIOVASCULAR DIABETOLOGY (2018)
Cardiomyocyte-specific deletion of Sirt1 gene sensitizes myocardiumto ischaemia and reperfusion injury
Lin Wang et al.
CARDIOVASCULAR RESEARCH (2018)
Canagliflozin and Heart Failure in Type 2 Diabetes Mellitus: Results From the CANVAS Program
Karin Radholm et al.
CIRCULATION (2018)
Is metformin beneficial for heart failure in patients with type 2 diabetes?
Milton Packer
DIABETES RESEARCH AND CLINICAL PRACTICE (2018)
CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of Sirt1
Yu -Pei Yuan et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2018)
Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction
Sebastiano Sciarretta et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)
Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia- reperfusion injury
Michael Koeppen et al.
NATURE COMMUNICATIONS (2018)
High Basolateral Glucose Increases Sodium-Glucose Cotransporter 2 and Reduces Sirtuin-1 in Renal Tubules through Glucose Transporter-2 Detection
Hiroyuki Umino et al.
SCIENTIFIC REPORTS (2018)
Canagliflozin inhibits interleukin-1 beta-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms
Sarah J. Mancini et al.
SCIENTIFIC REPORTS (2018)
Empagliflozin Induces Transient Diuresis Without Changing Long-Term Overall Fluid Balance in Japanese Patients With Type 2 Diabetes
Atsutaka Yasui et al.
DIABETES THERAPY (2018)
Empagliflozin Induces Transient Diuresis Without Changing Long-Term Overall Fluid Balance in Japanese Patients With Type 2 Diabetes
Atsutaka Yasui et al.
DIABETES THERAPY (2018)
Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1 alpha via downregulation of prolyl hydroxylase 3
Jan Neckar et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)
AMPK2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation
Bei Wang et al.
CIRCULATION RESEARCH (2018)
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases
Alice E. Kane et al.
CIRCULATION RESEARCH (2018)
The Impact of Moderate Chronic Hypoxia and Hyperoxia on the Level of Apoptotic and Autophagic Proteins in Myocardial Tissue
Alexandra Gyongyosi et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)
HIF-1, Metabolism, and Diabetes in the Embryonic and Adult Heart
Radka Cerychova et al.
FRONTIERS IN ENDOCRINOLOGY (2018)
Sitagliptin Protects Cardiac Function by Reducing Nitroxidative Stress and Promoting Autophagy in Zucker Diabetic Fatty (ZDF) Rats
Yi Zhou et al.
CARDIOVASCULAR DRUGS AND THERAPY (2018)
Dapagliflozin Attenuates Na+/H+ Exchanger-1 in Cardiofibroblasts via AMPK Activation
Yumei Ye et al.
CARDIOVASCULAR DRUGS AND THERAPY (2018)
Increased Cardiac Uptake of Ketone Bodies and Free Fatty Acids in Human Heart Failure and Hypertrophic Left Ventricular Remodeling
Gabor Voros et al.
CIRCULATION-HEART FAILURE (2018)
Experimental diabetes mellitus exacerbates ischemia/reperfusion-induced myocardial injury by promoting mitochondrial fission: Role of down-regulation of myocardial Sirt1 and subsequent Akt/Drp1 interaction
Aibin Tao et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)
An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity
Troy C. Krzysiak et al.
MOLECULAR CELL (2018)
Chronic O-GlcNAcylation and Diabetic Cardiomyopathy: The Bitterness of Glucose
Simon Ducheix et al.
FRONTIERS IN ENDOCRINOLOGY (2018)
High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions
Birsen Elibol et al.
FRONTIERS IN ENDOCRINOLOGY (2018)
Impacts of Diabetes and an SGLT2 Inhibitor on the Glomerular Number and Volume in db/db Mice, as Estimated by Synchrotron Radiation Micro-CT at SPring-8
Yumi Takiyama et al.
EBIOMEDICINE (2018)
How Does Empagliflozin Reduce Cardiovascular Mortality? Insights From a Mediation Analysis of the EMPA-REG OUTCOME Trial
Silvio E. Inzucchi et al.
DIABETES CARE (2018)
Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation
Laween Uthman et al.
DIABETOLOGIA (2018)
Effects of dapagliflozin on human epicardial adipose tissue: modulation of insulin resistance, inflammatory chemokine production, and differentiation ability
Esther Diaz-Rodriguez et al.
CARDIOVASCULAR RESEARCH (2018)
Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts
Masashi Mizuno et al.
PHYSIOLOGICAL REPORTS (2018)
Cardiac effects of SGLT2 inhibitors: the sodium hypothesis
Edoardo Bertero et al.
CARDIOVASCULAR RESEARCH (2018)
Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis
Karen M. Hallow et al.
DIABETES OBESITY & METABOLISM (2018)
Sirt1: Role Under the Condition of Ischemia/Hypoxia
Xiaofei Meng et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2017)
Dapagliflozin Binds Specifically to Sodium-Glucose Cotransporter 2 in the Proximal Renal Tubule
Chiara Ghezzi et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)
Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts
Tsung-Ming Lee et al.
FREE RADICAL BIOLOGY AND MEDICINE (2017)
Sodium-dependent glucose transporters (SGLT) in human ischemic heart: A new potential pharmacological target
Alessandra Di Franco et al.
INTERNATIONAL JOURNAL OF CARDIOLOGY (2017)
Effects of Canagliflozin on Cardiovascular Biomarkers in Older Adults With Type 2 Diabetes
James L. Januzzi et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)
Cigarette Smoking and Adipose Tissue: The Emerging Role in Progression of Atherosclerosis
Zhiyan Wang et al.
MEDIATORS OF INFLAMMATION (2017)
Liraglutide relieves myocardial damage by promoting autophagy via AMPK-mTOR signaling pathway in zucker diabetic fatty rat
Ya Zhang et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2017)
Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity
Lan Cui et al.
TOXICOLOGY LETTERS (2017)
The Autophagy Machinery: A New Player in Chemotactic Cell Migration
Pierre-Michael Coly et al.
FRONTIERS IN NEUROSCIENCE (2017)
Effects of Sodium-Glucose Cotransporter 2 Inhibitors for the Treatment of Patients With Heart Failure Proposal of a Novel Mechanism of Action
Milton Packer et al.
JAMA CARDIOLOGY (2017)
SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice
Liang Xu et al.
EBIOMEDICINE (2017)
Carbohydrate restriction ameliorates nephropathy by reducing oxidative stress and upregulating HIF-1α levels in type-1 diabetic rats
Pawan Krishan et al.
JOURNAL OF DIABETES AND METABOLIC DISORDERS (2017)
Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1-mediated autophagy regulation
Jun Ren et al.
AGING CELL (2017)
Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney
Motohiro Sasaki et al.
DIABETES (2017)
Cobalt(II) Chloride Modifies the Phenotype of Macrophage Activation
Mona Kumanto et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2017)
SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor
Yumei Ye et al.
CARDIOVASCULAR DRUGS AND THERAPY (2017)
Loop diuretics, renal function and clinical outcome in patients with heart failure and reduced ejection fraction
Kevin Damman et al.
EUROPEAN JOURNAL OF HEART FAILURE (2016)
Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy
Jordan J. Bartlett et al.
BIOCHEMICAL JOURNAL (2016)
The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1 accumulation and fibrosis in hypoxic adipose tissue
Xiaole Li et al.
BRITISH JOURNAL OF PHARMACOLOGY (2016)
The Failing Heart Relies on Ketone Bodies as a Fuel
Gregory Aubert et al.
CIRCULATION (2016)
Acute Pharmacodynamic Effects of Empagliflozin With and Without Diuretic Agents in Patients With Type 2 Diabetes Mellitus
Tim Heise et al.
CLINICAL THERAPEUTICS (2016)
Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes
Ele Ferrannini et al.
DIABETES (2016)
The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels
Simon A. Hawley et al.
DIABETES (2016)
Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study? A Unifying Hypothesis
Sunder Mudaliar et al.
DIABETES CARE (2016)
CV Protection in the EMPA-REG OUTCOME Trial: A Thrifty Substrate Hypothesis
Ele Ferrannini et al.
DIABETES CARE (2016)
Dapagliflozin Enhances Fat Oxidation and Ketone Production in Patients With Type 2 Diabetes
Giuseppe Daniele et al.
DIABETES CARE (2016)
Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial
David Fitchett et al.
EUROPEAN HEART JOURNAL (2016)
Time-dependent activity of Na+/H+ exchanger isoform 1 and homeostasis of intracellular pH in astrocytes exposed to CoCl2 treatment
Peng Wang et al.
MOLECULAR MEDICINE REPORTS (2016)
Sirt1 and the Mitochondria
Bor Luen Tang
MOLECULES AND CELLS (2016)
Hypoxia induces autophagy in cardiomyocytes via a hypoxia-inducible factor 1-dependent mechanism
Lan Gui et al.
EXPERIMENTAL AND THERAPEUTIC MEDICINE (2016)
Dapagliflozin, SGLT2 Inhibitor, Attenuates Renal Ischemia-Reperfusion Injury
Yoon-Kyung Chang et al.
PLOS ONE (2016)
Chronic intermittent hypoxia induces cardiac inflammation and dysfunction in a rat obstructive sleep apnea model
Qin Wei et al.
JOURNAL OF BIOMEDICAL RESEARCH (2016)
Cardioprotective HIF-1α-frataxin signaling against ischemia-reperfusion injury
Gayani Nanayakkara et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)
HIF-1α and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages
Ahmed Tawakol et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)
EPAS1/HIF-2α is a driver of mammalian pexophagy
Miriam J. Schoenenberger et al.
AUTOPHAGY (2015)
Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes
Hiromitsu Kanamori et al.
AUTOPHAGY (2015)
SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia
Hyun-Yoo Joo et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Autophagy and mitophagy in diabetic cardiomyopathy
Satoru Kobayashi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)
Hypoxia Decreases Glucagon-Like Peptide-1 Secretion from the GLUTag Cell Line
Yoshitaka Kihira et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2015)
Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling
Alexander V. Zhdanov et al.
EXPERIMENTAL CELL RESEARCH (2015)
Rapamycin Inhibition of mTOR Reduces Levels of the Na plus /H plus Exchanger 3 in Intestines of Mice and Humans, Leading to Diarrhea
Jun Yang et al.
GASTROENTEROLOGY (2015)
Development of autophagy inducers in clinical medicine
Beth Levine et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Sirt1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet
Xiaojun Liu et al.
JOURNAL OF HEPATOLOGY (2015)
Acute SGLT inhibition normalizes O-2 tension in the renal cortex but causes hypoxia in the renal medulla in anaesthetized control and diabetic rats
Julie O'Neill et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2015)
Interactions between HIF-1α and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease
Hui Li et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2015)
Hypoxia signaling pathways: modulators of oxygen-related organelles
Miriam J. Schonenberger et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2015)
The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice
Lindsey B. Gano et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2014)
HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore
Sang-Ging Ong et al.
CARDIOVASCULAR RESEARCH (2014)
Hif-2α Promotes Degradation of Mammalian Peroxisomes by Selective Autophagy
Katharina M. Walter et al.
CELL METABOLISM (2014)
PPARγ-Induced Stimulation of Amiloride-Sensitive Sodium Current in Renal Collecting Duct Principal Cells is Serum and Insulin Dependent
Ahmed Chraibi et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2014)
Macrophage HIF-2α Ameliorates Adipose Tissue Inflammation and Insulin Resistance in Obesity
Sung Sik Choe et al.
DIABETES (2014)
Effect of the sodium glucose co-transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus
S. Sha et al.
DIABETES OBESITY & METABOLISM (2014)
Neovascularization induced by hypoxia inducible transcription factor is associated with the improvement of cardiac dysfunction in experimental autoimmune myocarditis
Yuko Tada et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2014)
Hypoxia-inducible Factor-1α (HIF-1α) Protein Diminishes Sodium Glucose Transport 1 (SGLT1) and SGLT2 Protein Expression in Renal Epithelial Tubular Cells (LLC-PK1) under Hypoxia
Juan R. Zapata-Morales et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
Ele Ferrannini et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function
Marianne T. Neary et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)
Deletion of Hypoxia-Inducible Factor-1α in Adipocytes Enhances Glucagon-Like Peptide-1 Secretion and Reduces Adipose Tissue Inflammation
Yoshitaka Kihira et al.
PLOS ONE (2014)
Conditional Knockout of Prolyl Hydroxylase Domain Protein 2 Attenuates High Fat-Diet-Induced Cardiac Dysfunction in Mice
Heng Zeng et al.
PLOS ONE (2014)
HIF-lα and HIF-2α are critically involved in hypoxia-induced lipid accumulation in hepatocytes through reducing PGC-lα-mediated fatty acid β-oxidation
Yanlong Liu et al.
TOXICOLOGY LETTERS (2014)
Remote ischemic preconditioning regulates HIF-1α levels, apoptosis and inflammation in heart tissue of cardiosurgical patients: a pilot experimental study
Martin Albrecht et al.
BASIC RESEARCH IN CARDIOLOGY (2013)
Chronic hypoxia leads to a glycolytic phenotype and suppressed HIF-2 signaling in PC12 cells
Alexander V. Zhdanov et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)
Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart
Hideyuki Maeda et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)
Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation
Silvia Bijland et al.
CLINICAL SCIENCE (2013)
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy
Munehiro Kitada et al.
CLINICAL SCIENCE (2013)
Insulin Suppresses Atrophy- and Autophagy-related Genes in Heart Tissue and Cardiomyocytes Through AKT/FOXO Signaling
S. Paula-Gomes et al.
HORMONE AND METABOLIC RESEARCH (2013)
Enhanced autophagy ameliorates cardiac proteinopathy
Md. Shenuarin Bhuiyan et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Treatment of Anemia with Darbepoetin Alfa in Systolic Heart Failure
Karl Swedberg et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Impaired myocardial autophagy linked to energy metabolism disorders
Zi-Lun Li et al.
AUTOPHAGY (2012)
Unfavourable consequences of chronic cardiac HIF-1 stabilization
Marion Hoelscher et al.
CARDIOVASCULAR RESEARCH (2012)
Long-Term Safety, Tolerability, and Weight Loss Associated With Metformin in the Diabetes Prevention Program Outcomes Study
George A. Bray et al.
DIABETES CARE (2012)
Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation
William C. Hallows et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions
Alexander Laemmle et al.
PLOS ONE (2012)
Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling
Hong Wei et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2
Matthew D. Hirschey et al.
AGING-US (2011)
被撤回的出版物: Role of hypoxia-inducible factors in the dexrazoxane-mediated protection of cardiomyocytes from doxorubicin-induced toxicity (Retracted article. See MAY, 2020)
R. D. Spagnuolo et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation
Ana Planavila et al.
CARDIOVASCULAR RESEARCH (2011)
Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice
Zhonglin Xie et al.
DIABETES (2011)
Resveratrol attenuates acute hypoxic injury in cardiomyocytes: Correlation with inhibition of iNOS-NO signaling pathway
Shijun Wang et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
Hypoxia-Inducible Transcription Factor 2α Promotes Steatohepatitis Through Augmenting Lipid Accumulation, Inflammation, and Fibrosis
Aijuan Qu et al.
HEPATOLOGY (2011)
Hypoxia Increases Sirtuin 1 Expression in a Hypoxia-inducible Factor-dependent Manner
Rui Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
An Intact Canonical NF-κB Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia
Susan F. Fitzpatrick et al.
JOURNAL OF IMMUNOLOGY (2011)
The Aging Heart and Post-Infarction Left Ventricular Remodeling
Henry Shih et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)
SGLT2 Mediates Glucose Reabsorption in the Early Proximal Tubule
Volker Vallon et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death
B. Kucejova et al.
ONCOGENE (2011)
Sirtuin-1 regulation of mammalian metabolism
Matthew P. Gillum et al.
TRENDS IN MOLECULAR MEDICINE (2011)
Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia
Pinelopi P. Kapitsinou et al.
BLOOD (2010)
Profound Cardioprotection With Chloramphenicol Succinate in the Swine Model of Myocardial Ischemia-Reperfusion Injury
Javier A. Sala-Mercado et al.
CIRCULATION (2010)
Hearts of Hypoxia-inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection against Acute Ischemia-Reperfusion Injury
Jaana Hyvarinen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Chronic Inhibition of Hypoxia-inducible Factor Prolyl 4-hydroxylase Improves Ventricular Performance, Remodeling, and Vascularity After Myocardial Infarction in the Rat
Weike Bao et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2010)
Hypoxia-inducible factor-2α-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization
Alexander Paliege et al.
KIDNEY INTERNATIONAL (2010)
Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
Ji-Hong Lim et al.
MOLECULAR CELL (2010)
Conditional HIF-1α Expression Produces a Reversible Cardiomyopathy
Raffi Bekeredjian et al.
PLOS ONE (2010)
Activation of a HIF1α-PPARγ Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy
Jaya Krishnan et al.
CELL METABOLISM (2009)
Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes
Shweta Rane et al.
CIRCULATION RESEARCH (2009)
Hypoxia Inducible Factor-2α Stabilization and Maxi-K+ Channel β1-Subunit Gene Repression by Hypoxia in Cardiac Myocytes Role in Preconditioning
Lucia Bautista et al.
CIRCULATION RESEARCH (2009)
Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure
Susheel Gundewar et al.
CIRCULATION RESEARCH (2009)
Sirtuin 1 Functionally and Physically Interacts with Disruptor of Telomeric Silencing-1 to Regulate α-ENaC Transcription in Collecting Duct
Dongyu Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Hypoxia-inducible Factor 1α Induces Corticosteroid-insensitive Inflammation via Reduction of Histone Deacetylase-2 Transcription
Catherine E. Charron et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism
Erinn B. Rankin et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Carles Canto et al.
NATURE (2009)
FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
Matthew J. Potthoff et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1
Elhadji M. Dioum et al.
SCIENCE (2009)
Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt
Mayuko F. Kato et al.
JOURNAL OF HYPERTENSION (2008)
Activation of hypoxia-inducible factor-1 via prolyl-4 hydoxylase-2 gene silencing attenuates acute inflammatory responses in postischemic myocardium
Ramesh Natarajan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
Reactive oxygen species activate the HIF-1α promoter via a functional NFκB site
Steve Bonello et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
AMPK activation inhibits the expression of HIF-1α induced by insulin and IGF-1
C Treins et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
I Papandreou et al.
CELL METABOLISM (2006)
Regulation of erythropoietin production
KU Eckardt et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2005)
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
JT Rodgers et al.
NATURE (2005)
Human cardiomyocytes express high level of Na+/glucose cotransporter 1 (SGLT1)
LB Zhou et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2003)
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1α (HIF-1α):: Role of cytoplasmic trapping of HIF-2α
SK Park et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction
JI Nwogu et al.
CIRCULATION (2001)
Hypoxia-inducible factor-2α (HIF-2α) is involved in the apoptotic response to hypoglycemia but not to hypoxia
K Brusselmans et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Role of AMP-activated protein kinase in mechanism of metformin action
GC Zhou et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)
Effect of metformin on fatty acid and glucose metabolism in freshly isolated hepatocytes and on specific gene expression in cultured hepatocytes
JP Fulgencio et al.
BIOCHEMICAL PHARMACOLOGY (2001)
Share Paper
