Journal
CARCINOGENESIS
Volume 41, Issue 4, Pages 405-416Publisher
OXFORD UNIV PRESS
DOI: 10.1093/carcin/bgaa039
Keywords
-
Categories
Funding
- Lilly innovation fellowship award
- National Institutes of Health
- C3 Pedal the Cause grant
Ask authors/readers for more resources
Nuclear factor erythroid 2-related factor 2 (NRF2) is a master transcriptional regulator of genes whose products defend our cells for toxic and oxidative insults. Although NRF2 activation may reduce cancer risk by suppressing oxidative stress and tumor-promoting inflammation, many cancers exhibit elevated NRF2 activity either due to mutations that disrupt the negative control of NRF2 activity or other factors. Importantly, NRF2 activation is associated with poor prognosis and NRF2 has turned out to be a key activator of cancer-supportive anabolic metabolism. In this review, we summarize the diverse roles played by NRF2 in cancer focusing on metabolic reprogramming and tumor-promoting inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available