Journal
CARBOHYDRATE POLYMERS
Volume 244, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116432
Keywords
Glycol chitosan; Hyaluronic acid; Thermo-irreversible sol-gel; Cell binding affinity; Injectable tissue engineering
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Funding
- National Research Foundation - ministry of Science and ICT, Korea [NRF-2016M3A9B4919639, NRF-2019M3E5D1A02068573, NRF-2016M3A9B4919655, NRF-2019M3A9H1103331]
- National Research Foundation of Korea [2019M3A9H1103331, 2019M3E5D1A02068573, 2016M3A9B4919655, 2016M3A9B4919639] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Thermogels that undergo temperature-dependent sol-gel transition have recently attracted attention as a promising biomaterial for injectable tissue engineering. However, conventional thermogels usually suffer from poor physical properties and low cell binding affinity, limiting their practical applications. Here, a simple approach for developing a new thermogel with enhanced physical properties and cell binding affinity is proposed. This thermogel (AcHA/HGC) was obtained by simple blending of a new class of polysaccharide-based thermogel, N-hexanoyl glycol chitosan (HGC), with a polysaccharide possessing good cell binding affinity, acetylated hyaluronic acid (AcHA). Gelation of AcHA/HGC was initially triggered by the thermosensitive response of HGC and gradually intensified by additional physical crosslinking mechanisms between HGC and AcHA, resulting in thermo-irreversible gelation. Compared to the thermos-reversible HGC hydrogel, the thermo-irreversible AcHA/HGC hydrogel exhibited enhanced physical stability, mechanical properties, cell binding affinity, and tissue compatibility. These results suggest that our thermo-irreversible hydrogel is a promising biomaterial for injectable tissue engineering.
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