Journal
CELL
Volume 165, Issue 6, Pages 1312-1313Publisher
CELL PRESS
DOI: 10.1016/j.cell.2016.05.061
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Funding
- NIA NIH HHS [R01 AG027237, P01 AG047200, R01 AG046320] Funding Source: Medline
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Progerin, a mutated lamin A, causes the severe premature-aging syndrome Hutchinson-Gilford progeria (HGPS). Kubben et al. present a driving mechanism for HGPS involving trapping of NRF2 at the nuclear periphery by progerin. This local restriction results in impaired NRF2 signaling and chronic oxidative stress.
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