Journal
CELL
Volume 165, Issue 1, Pages 15-17Publisher
CELL PRESS
DOI: 10.1016/j.cell.2016.03.002
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The activation state of mTORC1, a master regulator of cell growth, is particularly sensitive to changes in the intracellular levels of the amino acid arginine, but the sensing mechanisms are poorly understood. In this issue of Cell, Chantranupong et al. identify CASTOR1 as a direct arginine sensor that acts through the GATOR2 complex to regulate mTORC1.
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