Journal
CANCER CELL
Volume 37, Issue 4, Pages 456-470Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2020.03.008
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Funding
- American Cancer Society [129098-RSG-16-092-01-TBG]
- National Cancer Institute [RO1CA240526, RO1CA236864]
- Chan Zuckerberg Initiative [HCA-A-1704-01668]
- Emerson Collective Cancer Research Fund [144300-80121457-19]
- CPRIT Single Cell Genomics Center [RP180684]
- MD Anderson Moonshot Program
- Morgan Welch Inflammatory Breast Cancer Program
- SWOG Hope Foundation
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Single-cell sequencing (SCS) has impacted many areas of cancer research and improved our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and therapeutic resistance. The development and refinement of SCS technologies has led to massive reductions in costs, increased cell throughput, and improved reproducibility, paving the way for clinical applications. However, before translational applications can be realized, there are a number of logistical and technical challenges that must be overcome. This review discusses past cancer research studies, emerging technologies, and future clinical applications that are bound to transform cancer medicine.
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