Journal
CANCER BIOMARKERS
Volume 28, Issue 4, Pages 421-427Publisher
IOS PRESS
DOI: 10.3233/CBM-191026
Keywords
Gliblastoma; LINC00174; oncogene; prognosis; proliferation
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Funding
- Beijing Talents Foundation from Organization department of Municipal committee of the CPC [2017000021223ZK32]
- National Natural Science Foundation of China [81902528]
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OBJECTIVE: To investigate the expression pattern, prognostic value and biological functional of LINC00174 in glioma. METHODS: In total, 140 glioma samples were collected as discovery cohort. TCGA RNA sequence dataset was obtained as validation set. Kaplan-Meier survival and multivariate Cox analysis were performed to evaluate survival difference. Furthermore, the biological function of LINC00174 was analyzed by clonogenic and intracranial tumor model assays. RESULTS: Overexpressed LINC00174 was significantly correlated with tumor grade as well as the higher mortality in survival analysis both in the discovery and the validation GBM cohorts. Besides, LINC00174 served as an independent prognostic indicator in glioblastoma patients. Additionally, knock down of LINC00174 expression significantly suppressed GBM cells' proliferation both in vitro and vivo. CONCLUSION: LINC00174 acts as an oncogene in glioma and may be a new potential therapeutic target.
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