Journal
CELL
Volume 165, Issue 4, Pages 801-811Publisher
CELL PRESS
DOI: 10.1016/j.cell.2016.04.041
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Funding
- Kenneth Rainin Foundation
- Crohn's and Colitis Foundation of America Award
- EMBO [1648]
- ERC, EU [647274]
- FCT, Portugal
- European Research Council (ERC) [647274] Funding Source: European Research Council (ERC)
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Multidirectional interactions between the nervous and immune systems have been documented in homeostasis and pathologies ranging from multiple sclerosis to autism, and from leukemia to acute and chronic inflammation. Recent studies have addressed this crosstalk using cell-specific targeting, novel sequencing, imaging, and analytical tools, shedding light on unappreciated mechanisms of neuro-immune regulation. This Review focuses on neuro-immune interactions at barrier surfaces-mostly the gut, but also including the skin and the airways, areas densely populated by neurons and immune cells that constantly sense and adapt to tissue-specific environmental challenges.
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