Journal
CELL
Volume 165, Issue 7, Pages 1734-1748Publisher
CELL PRESS
DOI: 10.1016/j.cell.2016.05.001
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Funding
- Nancy Lurie Marks Foundation
- William Randolph Hearst Fund
- Leonard and Isabelle Goldenson Fund
- Edward and Anne Lefler Foundation
- NSF
- Sackler Scholarship in Psychobiology
- European Molecular Biology Organization [ALTF 379-2011]
- Human Frontiers Science Program [LT001086/2012]
- Belgian American Educational Foundation
- Alice and Joseph E. Brooks Foundation
- Astellas Foundation for Research on Metabolic Disorders
- Japan Society for the Promotion of Science
- NIDA F31 [DA036922-01]
- Howard Hughes Medical Institute
- Burroughs Wellcome Fund
- Searle Foundation
- Sloan Foundation
- Vallee Foundation
- McKnight Foundation
- Khodadad Program
- National Institutes of Health [DP2OD007109, RO11DC011558]
- Global Brain Initiative from the Simons Foundation
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Odor perception in mammals is mediated by parallel sensory pathways that convey distinct information about the olfactory world. Multiple olfactory subsystems express characteristic seven-transmembrane G-protein-coupled receptors (GPCRs) in a one-receptor-per-neuron pattern that facilitates odor discrimination. Sensory neurons of the necklace'' subsystem are nestled within the recesses of the olfactory epithelium and detect diverse odorants; however, they do not express known GPCR odor receptors. Here, we report that members of the four-pass transmembrane MS4A protein family are chemosensors expressed within necklace sensory neurons. These receptors localize to sensory endings and confer responses to ethologically relevant ligands, including pheromones and fatty acids, in vitro and in vivo. Individual necklace neurons co-express many MS4A proteins and are activated by multiple MS4A ligands; this pooling of information suggests that the necklace is organized more like subsystems for taste than for smell. The MS4As therefore define a distinct mechanism and functional logic for mammalian olfaction.
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