Journal
CELL
Volume 165, Issue 1, Pages 192-206Publisher
CELL PRESS
DOI: 10.1016/j.cell.2016.02.033
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Funding
- NIH/NINDS [1DP2OD006514-01, TR01 1R01NS076467-01, 1U01NS090449-01]
- IARPA via DoI/IBC [D16PC00002]
- Conte [1P50MH094271-01]
- MURI Army Research Office [W911NF1210594, IIS-1447786]
- NSF [OIA-1125087, IIS-1110955]
- Human Frontier Science Program [RGP0051/2014]
- NIH
- NIGMS via the National Center for Multiscale Modeling of Biological Systems [P41GM10371]
- U.S. Department of Defense (DOD) [W911NF1210594] Funding Source: U.S. Department of Defense (DOD)
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In an attempt to chart parallel sensory streams passing through the visual thalamus, we acquired a 100-trillion-voxel electron microscopy (EM) dataset and identified cohorts of retinal ganglion cell axons (RGCs) that innervated each of a diverse group of postsynaptic thalamocortical neurons (TCs). Tracing branches of these axons revealed the set of TCs innervated by each RGC cohort. Instead of finding separate sensory pathways, we found a single large network that could not be easily subdivided because individual RGCs innervated different kinds of TCs and different kinds of RGCs co-innervated individual TCs. We did find conspicuous network subdivisions organized on the basis of dendritic rather than neuronal properties. This work argues that, in the thalamus, neural circuits are not based on a canonical set of connections between intrinsically different neuronal types but, rather, may arise by experience-based mixing of different kinds of inputs onto individual postsynaptic cells.
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