Journal
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
Volume 93, Issue 6, Pages 790-793Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/bcsj.20200021
Keywords
Ferritin; Protein-PNIPAM complexes; Polymer-binding peptides
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The development of protein-polymer complexes using protein cages is garnering attention as a strategy to overcome challenges that relate to immunogenicity and protease degradation. We propose the use of thermoresponsive polymers such as poly(N-isopropylacrylamide) (PNIPAM) to form ferritin-polymer complexes through non-covalent interactions. Ferritin is observed to be released from the complexes after 1-2 days incubation at 37 degrees C.
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