Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 168, Issue 6, Pages 730-733Publisher
SPRINGER
DOI: 10.1007/s10517-020-04790-0
Keywords
prenatal stress; ultrasound effect; autism spectrum disorder; autism model; rat offspring
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We studied the possibility of developing an autism model based on chronic prenatal psychological stress caused by variable frequency ultrasound 20-45 kHz. The offspring of female rats stressed during pregnancy demonstrated reduced time of social contacts in the social interaction test, increased anxiety in the open-field test, and memory impairment in the Morris water maze test in comparison with the control (intact) rat offspring. We also found a reducing trend in the BDNF gene expression in the amygdala in males of the experimental group. The results showed the possibility of developing the animal autism model based on prenatal stress.
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