Journal
BRITISH JOURNAL OF OPHTHALMOLOGY
Volume 105, Issue 3, Pages 392-396Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/bjophthalmol-2019-315595
Keywords
glaucoma; imaging; intraocular pressure; retina; treatment medical
Categories
Funding
- Canadian Institutes of Health Research [311562]
- Natural Sciences and Engineering Research Council of Canada [RGPIN-2016-04227]
- Fonds de Recherche en Ophtalmologie de l'Universite de Montreal
- Fonds de Recherche du Quebec-Sante
- Glaucoma Research Society of Canada
Ask authors/readers for more resources
The study demonstrates a strong positive correlation between ocular rigidity and acute intraocular pressure elevation following intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF). This suggests that non-invasive measurement of OR could be a useful tool in identifying patients at risk of intraocular pressure spikes following IVI.
Background/aims To evaluate the non-invasive measurement of ocular rigidity (OR), an important biomechanical property of the eye, as a predictor of intraocular pressure (IOP) elevation after anti-vascular endothelial growth factor (anti-VEGF) intravitreal injection (IVI). Methods Subjects requiring IVI of anti-VEGF for a pre-existing retinal condition were enrolled in this prospective cross-sectional study. OR was assessed in 18 eyes of 18 participants by measurement of pulsatile choroidal volume change using video-rate optical coherence tomography, and pulsatile IOP change using dynamic contour tonometry. IOP was measured using Tono-Pen XL before and immediately following the injection and was correlated with OR. Results The average increase in IOP following IVI was 19 +/- 9 mm Hg, with a range of 7-33 mm Hg. The Spearman correlation coefficient between OR and IOP elevation following IVI was 0.796 (p<0.001), showing higher IOP elevation in more rigid eyes. A regression line was also calculated to predict the IOP spike based on the OR coefficient, such that IOP spike=664.17 mm Hg center dot mu LxOR + 4.59 mm Hg. Conclusion This study shows a strong positive correlation between OR and acute IOP elevation following IVI. These findings indicate that the non-invasive measurement of OR could be an effective tool in identifying patients at risk of IOP spikes following IVI.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available