Journal
BRIEFINGS IN FUNCTIONAL GENOMICS
Volume 19, Issue 5-6, Pages 377-389Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bfgp/elaa008
Keywords
OB-fold proteins; single-stranded DNA-binding proteins; genome stability; telomere; therapeutic intervention
Funding
- Council of Scientific and Industrial Research, India [09/466(0197) 2k18 EMR-7]
- Department of Science and Technology
- Indian Council of Medical Research
- Indian National Academy of Science [INSA/SP/SS/2017/448]
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Oligonucleotide/oligosaccharide-binding (OB)-fold proteins play essential roles in the regulation of genome and its correct transformation to the subsequent generation. To maintain the genomic stability, OB-fold proteins are implicated in various cellular processes including DNA replication, DNA repair, cell cycle regulation and maintenance of telomere. The diverse functional spectrums of OB-fold proteins are mainly due to their involvement in protein-DNA and protein-protein complexes. Mutations and consequential structural alteration in the OB-fold proteins often lead to severe diseases. Here, we have investigated the structure, function and mode of action of OB-fold proteins (RPA, BRCA2, DNA ligases and SSBs1/2) in cellular pathways and their relationship with diseases and their possible use in therapeutic intervention. Due to the crucial role of OB-fold proteins in regulating the key physiological process, a detailed structural understanding in the context of underlying mechanism of action and cellular complexity offers a new avenue to target OB-proteins for therapeutic intervention.
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