Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 181, Issue 2, Pages 347-359Publisher
SPRINGER
DOI: 10.1007/s10549-020-05622-5
Keywords
Sexual problems; Breast cancer; Endocrine treatment; Treatment-induced symptoms; Depression
Categories
Funding
- International Breast Cancer Study Group
- US National Cancer Institute
- Breast Cancer Research Foundation [16-185, 17-187, 18-003]
- Ipsen
- Pfizer
- IBCSG: Frontier Science and Technology Research Foundation
- Swiss Group for Clinical Cancer Research (SAKK)
- Cancer Research Switzerland
- Oncosuisse
- Cancer League Switzerland
- Foundation for Clinical Cancer Research of Eastern Switzerland (OSKK)
- Institute of Cancer Research Clinical Trials and Statistics Unit (ICR-CTSU) on behalf of the National Cancer Research Institute Breast Clinical Studies Group United Kingdom (NCRI-BCSG-ICR-CTSU Partnership) [Cancer Research UK] [A15955, CRUKE/03/022, CRUKE/03/023]
- National Institute for Health Research Royal Marsden/Institute of Cancer Research Biomedical Research Centre
- Alliance for Clinical Trials in Oncology [US NIH U10CA180821]
- SWOG [US NIH CA32102]
- ECOG-ACRIN Cancer Research Group [US NIH CA21115, CA16116]
- NRG Oncology [US NIH] [U10CA180868, U10CA180822, UG1CA189867]
- Breast Cancer Trials Australia New Zealand [NHMRC 351161, 510788, 1105058]
- TerSera
- National Institute for Health Research/Cambridge Biomedical Research Centre
- Canadian Cancer Trials Group [US NIH CA077202]
- Canadian Cancer Trials Group [Canadian Cancer Society Research Institute] [015469, 021039]
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Purpose Sexual dysfunction is an important concern of premenopausal women with early breast cancer. We investigated predictors of sexual problems in two randomized controlled trials. Methods A subset of patients enrolled in TEXT and SOFT completed global and symptom-specific quality-of-life indicators, CES-Depression and MOS-Sexual Problems measures at baseline, six, 12 and 24 months. Mixed models tested the association of changes in treatment-induced symptoms (baseline to 6 months), depression at 6 months, and age at randomization with changes in sexual problems over 2 years. Results Sexual problems increased by 6 months and persisted at this level. Overall, patients with more severe worsening of vaginal dryness, sleep disturbances and bone or joint pain at 6 months reported a greater increase in sexual problems at all time-points. Depression scores were significantly associated with sexual problems in the short-term. All other symptoms had a smaller impact on sexual problems. Age was not associated with sexual problems at any time-point. Conclusion Among several key symptoms, vaginal dryness, sleep disturbance, and bone and joint pain significantly predicted sexual problems during the first 2 years. Early identification of these symptoms may contribute to timely and tailored interventions.
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