Journal
BIOSENSORS & BIOELECTRONICS
Volume 164, Issue -, Pages -Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2020.112332
Keywords
Metal-organic frameworks; Electrochemiluminescence; Biosensor; Lumi nophore; Signal amplification; Modification
Categories
Funding
- National Natural Science Foundation of China [21778020, 21804046]
- Sci-tech Innovation Foundation of Huazhong Agriculture University [2662017PY042]
Ask authors/readers for more resources
Metal-organic frameworks (MOFs) as porous materials have attracted much attention in various fields such as gas storage, catalysis, separation, and nanomedical engineering. However, their applications in electrochemiluminescence (ECL) biosensing are limited due to the poor conductivity, lack of modification sites, low stability and specificity, and weak biocompatibility. Integrating the functional materials into MOF structures endows MOF composites with improved conductivity and stability and facilitates the design of ECL sensors with multifunctional MOFs, which are potentially advantageous over their individual components. This review summarizes the strategies for designing ECL-active MOF composites including using luminophore as a ligand, in situ encapsulation of luminophore within the framework, and post-synthetic modification. As-prepared MOF composites can serve as innovative emitters, luminophore carriers, electrode modification materials and coreaction accelerators in ECL biosensors. The sensing applications of ECl-active MOF composites in the past five years are highlighted including immunoassays, genosensors, and small molecule detection. Finally, the prospects and challenges associated with MOF composites and their related materials for ECL biosensing are tentatively proposed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available