Dietary vitamin A intake and the risk of ovarian cancer: a meta-analysis

BACKGROUND: Previous studies have demonstrated some associations between dieta vitamin A intake and ovarian cancer risk with an inconsistent relationship. We therefore performed the present study to further explore the association between them. METHODS: Databases of PubMed, Embase, and Web of Science were retrieved up to 8 September 1, 2019. Summarized relative risk (RR) with corresponding 95% confidence intervals (Cl) were calculated. Stata 14.0 software was used for data analysis. RESULTS: Fifteen articles involving 4882 cases and 443,179 participants were included in this meta-analysis. A positive association between dietary vitamin A intake and ovarian cancer risk was found (RR = 0.816, 95%Cl = 0.723-0.920, I-2 = 48.4%, P (for heterogeneity) = 0.019). Significant association was also found in case-control studies (RR = 0.769, 95%Cl = 0.655-0.902), but not in cohort studies. When we performed the analysis between ovarian cancer risk and geographic locations, we found an inverse association in North American populations (RR = 0.825, 95%Cl = 0.720-0.946), instead of other populations. CONCLUSIONS: In summary, findings from the present study suggested that higher die a intake of vitamin A may contribute to the lower development of ovarian cancer, especially among North Americans.